APMAdvances in Precision Medicine2424-85922424-9106WHIOCE PUBLISHING PTE. LTD.10.18063/apm.v6i1.233ArticleFecal Microbiota Transplantation against Gut  Colonization Using a Multidrug-Resistant Organismhttps://artdesignp.com/journal/APM/6/1/10.18063/apm.v6i1.233LeeSeul Ki,ChoiJi Eun,ShinChae Min,KimMi-Na2021612021-07-25Background: Fecal microbiota transplantation against gut colonization using  a multidrug-resistant organism is a technique used to treat infections through  normalizing the gut microbiota via fecal microbiota transplantation in patients  with confirmed colonization by carbapenem-resistant Enterobacteriaceae (CRE) or vancomycin-resistant enterococci (VRE) based on a fecal culture  test within the past one week. In this study, we aimed to determine the safety  and effectiveness of this technique. Methods: The safety and effectiveness  were assessed via a systematic review. A literature search was conducted  using five Korean databases, such as KoreaMed, and international databases,  including Ovid-MEDLINE, Ovid-EMBASE, and Cochrane Library. Results: Main results are described here. From the studies retrieved using the  aforementioned search strategy, the remaining 581 studies were screened  using the inclusion and exclusion criteria, resulting in the selection of nine  studies for further consideration. In terms of safety, many studies reported  deaths and adverse reactions associated with different causes. Fewer studies  reported the rate of colonization; however, the effect of colony rate was  inconsistent when compared to no treatment group. Additionally, none of the  studies assessed the recurrence rate, a decrease in the prevalence of diseases  related to infection by multidrug-resistant bacteria, and the quality of life.  Conclusion: Fecal bacterial colonization for the decolonization of intestinal  multidrug-resistant bacteria was evaluated using a technique that requires  further research as there is insufficient literature evidence to validate its  safety and efficacy in treating infections through normalizing the intestinal  flora of patients with confirmed colonization by CRE or VRE.Fecal microbiota transplantation,Gut colonization,Multidrug-resistant organism

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