APMAdvances in Precision Medicine2424-85922424-9106WHIOCE PUBLISHING PTE. LTD.10.18063/apm.v5i2.231ArticleRisk Factors Associated with Colistin-Resistant  Acinetobacter baumannii Infectionhttps://artdesignp.com/journal/APM/5/2/10.18063/apm.v5i2.231ChungHae-Sun,HahmChorong,LeeMiae2020522020-07-25Acinetobacter baumannii is an important cause of healthcare-associated  infections and is resistant to almost all antimicrobial agents, with strains  recently reported to be resistant to colistin. In this study, we aimed to identify  the risk factors associated with colistin-resistant A. baumannii infections  by comparing colistin-resistant and -susceptible A. baumannii isolates. We  retrospectively reviewed the medical records of 51 and 100 cases in which  colistin-resistant and -susceptible A. baumannii were isolated, respectively.  Univariate analysis showed that compared with patients with colistin-sensitive  infections, patients with colistin-resistant A. baumannii infections had a  combined pulmonary disease (P = 0.017), were admitted to intensive care unit  (P = 0.020), and had prior mechanical ventilation (P = 0.003), tracheostomy  (P = 0.043), percutaneous drainage (P = 0.070), hemodialysis (P = 0.002);  use of colistin (P = 0.000), carbapenem (P = 0.000), and teicoplanin (P =  0.004); and co-infection (P = 0.035). Multivariate analysis indicated that eight  variables were related to the likelihood of colistin-resistant A. baumannii infections: use of teicoplanin (odds ratio [OR]: 3.140, 95% confidence interval  [CI]: 0.529–18.650), prior hemodialysis (OR: 2.722, 95% CI: 0.851–8.709),  combined pulmonary disease (OR: 2.286, 95% CI: 0.998–5.283), prior use of  carbapenem (OR: 0.199, 95% CI: 0.863–5.603), co-infection (OR: 1.706, 95%  CI: 0.746–3.898), prior mechanical ventilation (OR: 1.614, 95% CI, 0.684– 3.809), intensive care unit admission (OR: 1.387, 95% CI: 0.560–3.435), and  prior tracheostomy (OR: 1.102, 95% CI: 0.344–3.527); however, no statistical  differences were observed. Although colistin use could not be proven in  multivariate analysis, the possibility of being a risk factor cannot be ruled out.Acinetobacter baumannii,Colistin,Risk factor

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