CBRCell Biology ResearchTBA2529-7627WHIOCE PUBLISHING PTE. LTD.10.18063/CBR.v7i2.1895ArticleFabrication and Characterization of Poly-(L-Lysine-co-L-Lactide-co-ε-Caprolactone)/Poly-L-Lactic Acid Porous Scaffoldshttps://artdesignp.com/journal/CBR/7/2/10.18063/CBR.v7i2.1895ZhangGen,FangJianjun,LiuWenjuan,CuiXiaozhou,LiuSha,LanYi,ZhangChao,ZhouZhihua2026722026-06-26Three-dimensional porous scaffold materials have been increasingly applied in the field of bone tissue engineering to provide a suitable microenvironment for the propagation of cells. Poly-(L-lysine-co-L-lactide-co-ε-caprolactone)/poly-L-lactic acid (PLL-b-PLA-b-PCL/PLA) porous scaffolds were prepared by using a thermally induced phase separation (TIPS) method. The influences of fabrication parameters, including mass ratio, polymer concentration and freezing temperature, on the morphology, porosity and compressive strength were studied. The optimum conditions for fabrication of the PLL-b-PLA-b-PCL/PLA porous scaffolds were determined as -30 ℃, PLL-b-PLA-b-PCL/PLA concentration of 16.0 wt%, and a mass ratio of 1:5 (PLL-b-PLA-b-PCL to PLA) for cell growth and proliferation. The PLL-b-PLA-b-PCL/PLA showed an interconnected porous structure and the pore size was about 30-70 μm. Such PLL-b-PLA-b-PCL/PLA porous scaffolds may be considered as a promising candidate for tissue engineering scaffolds supporting attachment and proliferation of cells.Poly-(L-lysine-co-L-lactide-co-ε-caprolactone),Poly-L-lactic acid,Scaffold,Morphology

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