APMAdvances in Precision Medicine2424-85922424-9106WHIOCE PUBLISHING PTE. LTD.10.18063/APM.v11i4.1864ArticleUltrasound-Guided Pectoral Nerve Block Type II Reduces Postoperative Opioid Requirements and Promotes Postoperative Recovery in Patients Undergoing Modified Radical Mastectomyhttps://artdesignp.com/journal/APM/11/4/10.18063/APM.v11i4.1864GanLu,MaYue20261142026-04-26Objective: This study examined whether ultrasound-guided Pecs II block reduces postoperative opioid consumption and improves recovery quality in patients undergoing modified radical mastectomy. Methods: One hundred female patients with breast cancer scheduled for elective modified radical mastectomy between June 2023 and December 2024 were enrolled. They were randomly allocated in a 1:1 ratio to either the Pecs II block group (experimental group, n = 50) or the control group (n = 50). After induction of general anesthesia, the experimental group received ultrasound-guided Pecs II block with 35 mL of 0.25% ropivacaine. The control group received an equal volume of normal saline. Cumulative opioid consumption (morphine equivalents) within 48 hours postoperatively, Numerical Rating Scale (NRS) pain scores at each time point, time to first rescue analgesia, Quality of Recovery-15 (QoR-15) scores, time to first ambulation, length of hospital stay, and incidence of adverse events were recorded. Results: Cumulative 48-hour opioid consumption was 9.6 ± 2.4 mg in the experimental group, significantly lower than 24.8 ± 4.2 mg in the control group (P < 0.001). NRS pain scores and rescue analgesia rates were reduced at all time points (P < 0.001). QoR-15 scores at 24 and 48 hours postoperatively, time to first ambulation, and length of hospital stay all favored the experimental group (P < 0.001). Conclusion: Thus, the findings indicate that this block could provide important benefits across the relevant postoperative recovery context. Evidence supports broader clinical use.Pecs II block,Ultrasound guidance,Modified radical mastectomy,Opioids,Postoperative recovery quality

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