APMAdvances in Precision Medicine2424-85922424-9106WHIOCE PUBLISHING PTE. LTD.10.18063/APM.v11i3.1667ArticleClinical Effects of Cognitive Behavioral Therapy Combined with Mindfulness Training on Emotional Regulation and Sleep Quality in Adolescents with Depressive Disordershttps://artdesignp.com/journal/APM/11/3/10.18063/APM.v11i3.1667LiYan20261132026-03-26Objective: This study aimed to investigate the intervention effects of cognitive behavioral therapy (CBT) combined with mindfulness training on emotional regulation ability and sleep quality in adolescents with depressive disorders, providing evidence for optimizing non-pharmacological intervention strategies for adolescent depression in clinical settings. Methods: A total of 200 adolescent patients with depressive disorders admitted to the psychiatric outpatient and inpatient departments of our hospital from February 2025 to February 2026 were selected and randomly divided into a control group (100 cases) and an observation group (100 cases). The control group received conventional antidepressant medication plus routine psychological care, while the observation group received CBT combined with mindfulness training in addition to the control group’s treatment. Both groups underwent an 8-week intervention period. Emotional state, emotional regulation ability, and sleep quality were assessed before and after the intervention, and adverse reactions were recorded. Results: After 8 weeks of intervention, compared with the control group, the observation group showed significantly lower scores on the Self-Rating Depression Scale (SDS), Self-Rating Anxiety Scale (SAS), Pittsburgh Sleep Quality Index (PSQI), and all dimensions and total scores of the Treatment Emergent Symptom Scale (TESS) (all P < 0.001). Scores on all dimensions of emotional regulation ability were significantly higher in the observation group (all P < 0.001). Conclusion: CBT combined with mindfulness training significantly improves depressive and anxious moods, enhances emotional regulation ability, and optimizes sleep quality in adolescents with depressive disorders, with good safety and clinical applicability.Cognitive behavioral therapy,Mindfulness training,Adolescent depressive disorders,Emotional regulation,Sleep quality

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