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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">APM</journal-id><journal-title-group><journal-title>Advances in Precision Medicine</journal-title></journal-title-group><issn>2424-8592</issn><eissn>2424-9106</eissn><publisher><publisher-name>WHIOCE PUBLISHING PTE. LTD.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18063/APM.v11i3.1643</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>SOX10 in Neurodevelopment and Disease: Molecular Mechanisms, Pathological Models and Therapeutic Prospects</title><url>https://artdesignp.com/journal/APM/11/3/10.18063/APM.v11i3.1643</url><author>YangXinping,LouJie,LiLi,ZhangTiesong</author><pub-date pub-type="publication-year"><year>2026</year></pub-date><volume>11</volume><issue>3</issue><history><date date-type="pub"><published-time>2026-03-26</published-time></date></history><abstract>SOX10 is a neural crest transcription factor that preserves lineage competence and guides differentiation. Because it functions in enteric progenitors, Schwann cells, melanocytes, and auditory-supporting cells, reduced activity can produce multisystem disease. This review links SOX10-centered regulation to Waardenburg syndrome, Hirschsprung disease, deafness, and glial dysfunction, and highlights models that support mechanism-based therapy design.</abstract><keywords>Neural crest,Neurocristopathy,Hirschsprung disease,Waardenburg syndrome,Schwann cell biology,Inner-ear homeostasis,Precision medicine</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1] Developmental Biology Kelsh RN, 2006, Sorting Out Sox10 Functions in Neural Crest Development. Bioessays, 28(8): 788&amp;ndash;798.
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