APMAdvances in Precision Medicine2424-85922424-9106WHIOCE PUBLISHING PTE. LTD.10.18063/APM.v11i3.1639ArticleApplication and Feasibility Study of High-Pressure CO₂ Sterilization Technology in Chinese Medicinal Materials Sterilizationhttps://artdesignp.com/journal/APM/11/3/10.18063/APM.v11i3.1639WangHongjie,GuanKuikui,TongWanying,ZhangTian20261132026-03-26Aiming at the risks of excessive microorganisms and irradiation sterilization residues in the direct use of raw powder of Chinese medicinal materials, this paper took the production line of a Chinese patent medicine enterprise as the engineering research object to study the engineering application of high-pressure CO₂ sterilization technology. With the designed sterilization conditions of pressure 30–60 MPa and temperature 35℃–65℃, the raw powder sterilization of medicinal materials with different medicinal parts was completed, and a technical parameter system for industrial application was established. During the project implementation, key technical problems, such as equipment pressure-bearing design, process energy consumption control and multi-round sterilization capacity improvement, were solved. The sterilization effect meets the pharmacopoeia standards, realizing the industrial application goal, and providing a green and safe technical alternative for the sterilization of raw powder of Chinese medicinal materials.High-pressure CO₂ sterilization,Raw powder of Chinese medicinal materials,Engineering application

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