Study on the Regulatory Mechanism and Targeted Therapy of Autophagy in Acute Respiratory Distress Syndrome

APM

Advances in Precision Medicine

2424-85922424-9106

WHIOCE PUBLISHING PTE. LTD.

10.18063/APM.v11i2.1413

Article

Study on the Regulatory Mechanism and Targeted Therapy of Autophagy in Acute Respiratory Distress Syndromehttps://artdesignp.com/journal/APM/11/2/10.18063/APM.v11i2.1413YangHuishu,LuNa

2026

112

2026-02-26

Acute Respiratory Distress Syndrome (ARDS) causes significant mortality worldwide, yet lacks specific pharmacological interventions. Autophagy, a critical cellular response to ARDS triggers like infection and hypoxia, regulates alveolar repair and immune modulation. Although macroautophagy is extensively characterized in ARDS, microautophagy and chaperone-mediated autophagy (CMA) remain poorly understood. This paper comprehensively reviews the molecular mechanisms of all three autophagy subtypes in ARDS, highlighting their potential as novel diagnostic markers and therapeutic targets.Macroautophagy, Microautophagy, Chaperone-mediated autophagy, Acute Respiratory Distress Syndrome

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