APMAdvances in Precision Medicine2424-85922424-9106WHIOCE PUBLISHING PTE. LTD.10.18063/APM.v11i2.1410ArticleExperimental Study on the Repair of Spinal Cord Injury by Induced Pluripotent Stem Cell (IPSC) Transplantationhttps://artdesignp.com/journal/APM/11/2/10.18063/APM.v11i2.1410GaoXiong,JeongDae-Keun20261122026-02-26Objective: To investigate the reparative effects of induced pluripotent stem cell (iPSC) transplantation on spinal cord injury (SCI) and its influence on neurological functional recovery. Methods: Based on previous animal experimental studies of SCI, the survival, differentiation characteristics, and motor function changes following transplantation of iPSC-derived neural stem cells were analyzed. Behavioral assessments and histological methods were employed to evaluate the therapeutic effects of transplantation. Results: After transplantation, iPSCs were able to survive in the injured spinal cord and differentiate into neurons, astrocytes, and oligodendrocytes. Compared with the control group, animals in the transplantation group showed significantly improved motor function scores (P < 0.05), accompanied by enhanced axonal regeneration and remyelination in the injured area. Conclusion: iPSC transplantation exerts a positive effect on promoting structural repair and functional recovery after spinal cord injury, indicating its potential therapeutic value.Induced Pluripotent Stem Cell, Spinal Cord Injury, Cell Transplantation, Neural Repair, Functional Recovery

[1] Tang C, Zhong DJ, 2017, Research Progress on Induced Pluripotent Stem Cells and Their Transplantation for the Treatment of Spinal Cord Injury. Chinese Journal of Spine and Spinal Cord, 27(4): 368–371. [2] Zhang S, Gu B, Li HN, et al., 2013, Current Status of Induced Pluripotent Stem Cells and Their Transplantation for Spinal Cord Injury. Acta Neuropharmacologica, 3(3): 57–64. [3] Yuan WC, Yuan H, Guo Y, et al., 2016, Mechanisms and Application Progress of Induced Pluripotent Stem Cells in Spinal Cord Injury Repair. Guangdong Medical Journal, 37(21): 3286–3289. [4] Yao SH, Zhong DJ, 2013, Application and Research Progress of Induced Pluripotent Stem Cell Transplantation in Spinal Cord Injury Repair. Chinese Journal of Spine and Spinal Cord, 23(11): 1015–1018. [5] Fan JJ, Wang JJ, Chen F, et al., 2021, Research Progress on Induced Pluripotent Stem Cell Transplantation for the Treatment of Spinal Cord Injury. Journal of Traditional Chinese Orthopedics and Traumatology, 33(2): 54–58. [6] Yang C, Shen CL, 2018, Research Progress on Induced Pluripotent Stem Cell Therapy for Cervical Spinal Cord Injury. Journal of Anhui Medical University, 53(2): 323-326. [7] Xia GM, Xu Q, Liu XQ, et al., 2021, Applications and Roles of Induced Pluripotent Stem Cells in Orthopedic Tissue Engineering. Chinese Journal of Tissue Engineering Research, 25(19): 3077-3082. [8] Li HM, Shen CL, 2019, Research Progress on Stem Cell Therapy for Spinal Cord Injury. Journal of Anhui Medical University, 54(4): 662-666. [9] Tu XS, 2014, Stem Cell Transplantation Experiments in Human Diseases: Current Status and Progress of Basic Research. Chinese Journal of Tissue Engineering Research, 18(45): 7364-7369. [10] Meng CY, 2013, Current Status and Prospects of Induced Pluripotent Stem Cell Therapy for Spinal Cord Injury. Journal of Jining Medical University, 36(3): 153-156.