APMAdvances in Precision Medicine2424-85922424-9106WHIOCE PUBLISHING PTE. LTD.10.18063/APM.v11i2.1391ArticleEffect of Sacubitril-valsartan Combined with Metoprolol in the Treatment of Refractory Heart Failure in the Elderlyhttps://artdesignp.com/journal/APM/11/2/10.18063/APM.v11i2.1391ZhouYuyan20261122026-02-26Objective: To explore the effect of sacubitril-valsartan combined with metoprolol in the treatment of refractory heart failure in the elderly. Methods: 72 elderly patients with refractory heart failure were selected for data analysis in the outpatient clinic of our hospital from January 2024 to October 2025. They were divided into groups using the random number table method, with 36 patients in each group. The research group was treated with sacubitril-valsartan combined with metoprolol, and the control group was treated with metoprolol. The data between the groups were compared. Results: Compared with the control group, the total effective rate of the study group was significantly higher, the NT-proBNP index was significantly lower after treatment, and the inflammatory factors were significantly lower after treatment, p < 0.05; the NT-proBNP index and inflammatory factors before treatment were compared between the two groups, and the incidence of adverse reactions between the two groups was compared, p > 0.05. Conclusion: The effect of sacubitril-valsartan combined with metoprolol in the treatment of refractory heart failure in the elderly is ideal.Sacubitril-valsartan, Metoprolol, Elderly, Refractory heart failure, Effect

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