APMAdvances in Precision Medicine2424-85922424-9106WHIOCE PUBLISHING PTE. LTD.10.18063/APM.v10i3.612ArticleTherapeutic Effect of Nasal Continuous Positive Airway Pressure Ventilation on Severe Pneumonia Complicated with Respiratory Failure in Childrenhttps://artdesignp.com/journal/APM/10/3/10.18063/APM.v10i3.612GuoXin,QiXusheng20251032025-09-26Objective: To explore the clinical effect of nasal continuous positive airway pressure (nCPAP) in children with severe pneumonia complicated with respiratory failure. Methods: 80 children were randomly divided into a control group and an observation group, 40 cases in each group. The control group was given routine treatment, and the observation group was given nCPAP intervention. The changes of oxygenation index, ventilation efficiency, respiratory load and inflammatory index were compared between the two groups. Results: After treatment, A-ADO decreased significantly, PaO2/FiO2 and Cdyn increased, PaCO2 decreased, pH increased, VE and VT improved, and f/VT decreased in the observation group. The ratio of CRP, PCT, WBC and neutrophil was significantly lower than that of the control group, with statistical significance (P < 0.05). Conclusion: nCPAP can effectively improve lung oxygenation, ventilation function and inflammatory state, reduce respiratory load, and promote recovery of children, and its clinical application value is significant.Transnasal,Continuous positive airway pressure ventilation,Severe pneumonia in children,Respiratory failure,Observation of curative effect

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